Flea Meds Dosage Chart

Flea Med Dosages for Cats & Dogs

By isak, September 25, 2016

I have dosed down flea meds for years and, knock on wood, have had no problems. Having several cats and dogs, this is the most economical way for me to do it. With all the cats and dogs there are in the world, HOW can flea meds be SO expensive? I recently came across this chart of dosages for several of the most common brands of flea meds and am reprinting it here for anyone else needing it.

Ask your vet for the correct dosing and medications for YOUR animal. This list is just a reference guide and is not intended to avoid veterinary guidance or advice.

Advantage (Imidacloprid)

Dog Product Insert
Cat Product Insert
Dose is 0.05ml/pound. Multiply 0.05 times your pet’s weight for the dose

(Package instructions)                                   (Used in lower doses with same effect)
Cats up to 9 pounds – 0.4ml                           0.4ml =   10lbs       |      0.6ml =   15lbs
Cats 10+ pounds  –       0.8ml                             0.8ml =   20lbs      |      1.0ml =   25lbs
Dogs 11-20 pounds  –  1.0ml                              1.2ml =   30lbs      |      1.6ml =   40lbs
Dogs 21-55 pounds  –  2.5ml                             2.0ml =   50lbs      |      2.4ml =   60lbs
Dogs 55+ pounds  –     4.0ml                              2.8ml =   70lbs      |      3.2ml =   80lbs
100lbs = 4.0ml                                                      4.0 ml = 80+lbs
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Frontline Plus (Fipronil & (s)-methoprene)

Dog Product Info
Cat Product Info

The dose is 0.0305ml/pound. Multiply 0.0305 times your pet’s weight for dose

(Package instructions)                      (Used in lower doses with same effect)
Cats     1-10 pounds –  0.5ml               0.3ml for  10lbs        0.45 for   15lbs
Dogs  11-22 pounds – 0.67ml              0.6ml for  20lbs        0.75 for   25lbs
Dogs  23-44 pounds – 1.34ml              0.9ml for  30lbs        1.5   for  50 lbs
Dogs  45-88 pounds – 2.68ml              1.8ml for  60lbs        2.68 for   88lbs
Dogs  89-132 pounds – 4.0ml              2.7ml for  90lbs        4.0   for 133lbs
NOTE: If you’re using Frontline Plus —
The amount of fipronil in the dog version is the same as in the cat version. The “Plus” is methoprene, an insect growth regulator. There’s LESS of it in the dog product than in the cat product, so it’s safe to use the dog product on the cats but do NOT use the cat product on a small dog.

Generic Frontline Plus for dogs may contain a different ingredient than the brand name. If a generic Frontline product contains something other than methoprene or fipronil it may not be safe on your cat.
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Revolution (selamectin)

Revolution® has a single active, safe in both cat and dog, but it’s concentration varies: the formulation for puppies, kittens and cat is half strength. If splitting a large dog vial and applying the volume stated on the packaging for a cat, a double dose would be given. Take careful note of the half volumes shown below (concentration: 60mg/ml vs 120 mg/ml). Product Insert

(based on 120mg per 1ml potencyDose is 0.025ml/pound. Multiply 0.025 times your pet’s weight for dose.)
0.0-5lb dog/ cat =  0.12 ml
5.1-10lb dog/cat = 0.25 ml
10.1-20lb dog/cat = 0.5 ml
20.1-40b dog         = 1.0 ml
40.1-85lb dog        = 2.0 ml
85.1-130lb dog      = 3.0 ml

(based on 60mg per 1ml potency. Dose is 0.05ml/pound. Multiply 0.05 times your pet’s weight for dose.)
Up to 5lb cat/dog = 0.25ml
5.1-15lb cat = 0.75ml
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Advantage Multi

 *Dose is 0.045ml/pound. Multiply 0.045 times your dog’s weight for dose
The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration

Product Info For Dogs / Product Insert for Dogs
Dogs          ML          Imidacloprid     Moxidectin
3-9 lb        0.4ml                40                   10        Advantage Multi 9
9.1-20 lb   1.0ml              100                   25        Advantage Multi 20
20.1-55lb  2.5ml              250                  62.5      Advantage Multi 55
55.1-88lb  4.0ml              400                 100        Advantage Multi 88
~~~~~~~~~~~ ~~~~~~~~~~~~ ~~~~~~~~~~~ ~~~~~~~~~~~~
*Dose is 0.045ml/lb. Multiply 0.045 times your cat’s weight for dose
The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Product Info For Cats / Product Insert for Cats

Cats          ML            Imidacloprid    Moxidectin
2-5lb       0.23ml                23                  2.3         Advantage Multi 5
5.1-9lb    0.4ml                  40                  4            Advantage Multi 9
9.1-18lb  0.8ml                  80                  8           Advantage Multi 18
*dosage is approximate my math calculations came out to be 0.05ml/lb, but there is a discrepancy with packaged dosages. Also there is more Moxidectin in the dog formula than in the cat formula, so I would not put dog product on cats*


NEVER USE THIS ON CATS. If you get Advantix® on your hands when splitting a vial for the dogs, do not touch your cat before thoroughly washing your hands with warm soapy water.

0-10 lbs = 0.4ml               41-50 lbs = 2.0ml
11-20 lbs = 0.8ml             51-60 lbs = 2.4ml
21-30 lbs = 1.2ml              61-70 lbs = 2.8ml
31-40 lbs = 1.6ml             71-80 lbs = 3.2ml


Flea Allergic pets, like those of us allergic to mosquito bites,  will incessantly itch and pull out all their hair if just one flea gets past the flea control. Given most spot on agents only achieve high kill rates, above 95%,  for the first 2 weeks of the month, twice monthly application is often recommended by dermatologists when treating flea allergy.

Storage of Unused Topicals

Manufacturers packaging protects the product from 2 important things: light and air. Drugs and insecticides can be destroyed and rendered ineffective if mishandled. Keep in the vial and store in a cool, dark place. The fridge is ideal, but under the sink or any other ‘chemical repository’ is ok.  Do not freeze. You may also decide to keep the entire flea medication in the syringe itself which is fine but far from ideal. I recommend an airtight glass vial.  The key point is no air exposure, no light, and no heat and they will last a very long time.

reprinted from Starlight Boston Terriers, Global Watchdog, and others.


  1. Mireille Brosset says:

    Check Dr. Foster & Smith for cheaper multi. They have a sale on this product now.

  2. Kim says:

    Thank you you so much for this info. We live on a farm and have 6 dogs ranging in size from 6 to 95 pounds. I had already.been splitting dosage vials between 2 dogs when appropriate. So recently I thought, why not try to let the product and our money go further by finding out the dose per pound that would be effective. This article was amazing in giving info on all of these products. It was also helpful to find out the important storage info. I wish that more people could be made aware of this info. It seems like it will be good for our pets to have only the necessary amount of insecticide as well. Thanks again for this very informative article.

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