Flea Meds Dosage Chart

Flea Med Dosages for Cats & Dogs

By isak, September 25, 2016

I have dosed down flea meds for years and, knock on wood, have had no problems. Having several cats and dogs, this is the most economical way for me to do it. With all the cats and dogs there are in the world, HOW can flea meds be SO expensive? I recently came across this chart of dosages for several of the most common brands of flea meds and am reprinting it here for anyone else needing it.

Ask your vet for the correct dosing and medications for YOUR animal. This list is just a reference guide and is not intended to avoid veterinary guidance or advice.

Advantage & Advantage II (Imidacloprid)

Advantage required adult fleas to ingest the medication, at which point they would be impacted by the insect-specific neurotoxins and die. Advantage II kills fleas on contact, with the addition of three new chemicals to its formula, that makes your dog or cat’s skin an entirely inhospitable environment for pests. Eggs are killed before they hatch. Adult fleas are killed and will fall off, or will be washed off in your dog’s next bath.

Dog Product Insert
Cat Product Insert
Dose is 0.05ml/pound. Multiply 0.05 times your pet’s weight for the dose

(Used in lower doses with same effect)
Cats up to 9 pounds – 0.4ml
Cats 10+ pounds  –       0.8ml
Dogs 11-20 pounds  –  1.0ml
Dogs 21-30 pounds  –  1.2ml
Dogs 31-40 pounds  –  1.6ml
Dogs 41-50 pounds  –  2.0ml
Dogs 51-60 pounds  –  2.4ml
Dogs 61-70 pounds  –  2.8ml
Dogs 71-80 pounds  –  3.2ml
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Frontline Plus (Fipronil & (s)-methoprene)

Dog Product Info
Cat Product Info

The dose is 0.0305ml/pound. Multiply 0.0305 times your pet’s weight for dose

(Package instructions)                      (Used in lower doses with same effect)
Cats     1-10 pounds –  0.5ml               0.3ml for  10lbs        0.45 for   15lbs
Dogs  11-22 pounds – 0.67ml              0.6ml for  20lbs        0.75 for   25lbs
Dogs  23-44 pounds – 1.34ml              0.9ml for  30lbs        1.5   for  50 lbs
Dogs  45-88 pounds – 2.68ml              1.8ml for  60lbs        2.68 for   88lbs
Dogs  89-132 pounds – 4.0ml              2.7ml for  90lbs        4.0   for 133lbs
NOTE: If you’re using Frontline Plus —
The amount of fipronil in the dog version is the same as in the cat version. The “Plus” is methoprene, an insect growth regulator. There’s LESS of it in the dog product than in the cat product, so it’s safe to use the dog product on the cats but do NOT use the cat product on a small dog.

Generic Frontline Plus for dogs may contain a different ingredient than the brand name. If a generic Frontline product contains something other than methoprene or fipronil it may not be safe on your cat.
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Revolution (selamectin)

Revolution® has a single active, safe in both cat and dog, but it’s concentration varies: the formulation for puppies, kittens and cat is half strength. If splitting a large dog vial and applying the volume stated on the packaging for a cat, a double dose would be given. Take careful note of the half volumes shown below (concentration: 60mg/ml vs 120 mg/ml). Product Insert

(based on 120mg per 1ml potencyDose is 0.025ml/pound. Multiply 0.025 times your pet’s weight for dose.)
0.0-5lb dog/ cat =  0.12 ml
5.1-10lb dog/cat = 0.25 ml
10.1-20lb dog/cat = 0.5 ml
20.1-40b dog         = 1.0 ml
40.1-85lb dog        = 2.0 ml
85.1-130lb dog      = 3.0 ml

(based on 60mg per 1ml potency. Dose is 0.05ml/pound. Multiply 0.05 times your pet’s weight for dose.)
Up to 5lb cat/dog = 0.25ml
5.1-15lb cat = 0.75ml
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Advantage Multi

 *Dose is 0.045ml/pound. Multiply 0.045 times your dog’s weight for dose
The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration

Product Info For Dogs / Product Insert for Dogs
Dogs          ML          Imidacloprid     Moxidectin
3-9 lb        0.4ml                40                   10        Advantage Multi 9
9.1-20 lb   1.0ml              100                   25        Advantage Multi 20
20.1-55lb  2.5ml              250                  62.5      Advantage Multi 55
55.1-88lb  4.0ml              400                 100        Advantage Multi 88
~~~~~~~~~~~ ~~~~~~~~~~~~ ~~~~~~~~~~~ ~~~~~~~~~~~~
*Dose is 0.045ml/lb. Multiply 0.045 times your cat’s weight for dose
The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Product Info For Cats / Product Insert for Cats

Cats          ML            Imidacloprid    Moxidectin
2-5lb       0.23ml                23                  2.3         Advantage Multi 5
5.1-9lb    0.4ml                  40                  4            Advantage Multi 9
9.1-18lb  0.8ml                  80                  8           Advantage Multi 18
*dosage is approximate my math calculations came out to be 0.05ml/lb, but there is a discrepancy with packaged dosages. Also there is more Moxidectin in the dog formula than in the cat formula, so I would not put dog product on cats*


NEVER USE THIS ON CATS. If you get Advantix® on your hands when splitting a vial for the dogs, do not touch your cat before thoroughly washing your hands with warm soapy water. Advantix causes permethrin toxicity in cats because they cannot metabolize the permethrin in Advantix.

0-10 lbs = 0.4ml               41-50 lbs = 2.0ml
11-20 lbs = 0.8ml             51-60 lbs = 2.4ml
21-30 lbs = 1.2ml              61-70 lbs = 2.8ml
31-40 lbs = 1.6ml             71-80 lbs = 3.2ml


Flea Allergic pets, like those of us allergic to mosquito bites,  will incessantly itch and pull out all their hair if just one flea gets past the flea control. Given most spot on agents only achieve high kill rates, above 95%,  for the first 2 weeks of the month, twice monthly application is often recommended by dermatologists when treating flea allergy.

Storage of Unused Topicals

Manufacturers packaging protects the product from 2 important things: light and air. Drugs and insecticides can be destroyed and rendered ineffective if mishandled. Keep in the vial and store in a cool, dark place. The fridge is ideal, but under the sink or any other ‘chemical repository’ is ok.  Do not freeze. You may also decide to keep the entire flea medication in the syringe itself which is fine but far from ideal. I recommend an airtight glass vial.  The key point is no air exposure, no light, and no heat and they will last a very long time.

reprinted from Starlight Boston Terriers, Global Watchdog, and others.


  1. Johanna Baumgartner says:

    Wow – This is such a work of love. Thank you so much. I have yet to totally figure everything out, but the concept of reducing the amount of flea medication is really important to me given the reactions and deaths that occur from some of these mediations. Thank you again.

  2. Sandy B says:

    What are your concerns and thoughts regarding Fluralaner (Bravecto) for dogs?

    • isak says:

      I don’t have any experience with Bravecto. Though it is touted as a 12-week solution for fleas and ticks, it seems that for the Lone Star tick, they recommend redosing every 8 weeks. You can read this endorsement from a vet in Canada. A “Freedom of Information Summary” [PDF] dated 15 May 2014 is available on the Food and Drug Administration’s (FDA) web site. It’s an interesting read. From it, there is this:

      There were no clinically-relevant, treatment-related effects on physical examinations, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation profiles and urinalysis), gross pathology, histopathology, or organ weights. Diarrhea, mucoid and bloody feces were the most common observations in this study, occurring at a similar incidence in the treated and control groups. Five of the twelve treated dogs that experienced one or more of these signs did so within 6 hours of the first dosing. One dog in the 3X group was observed to be dull, inappetent, with evidence of bloody diarrhea, vomiting and weight loss beginning five days following the first dose. One dog in the 1X group vomited food four hours following the first dose.

      So just be aware of the side effects you might encounter. And if you try it, let us know what you think. I’d love to share your experience with our readers.

  3. Adele says:

    I wanted to say thank you so much for all the information that is provided here. It has been such a help in figuring out dosage amounts of flea treatments for our animals. Like many people who visit this site, we take in strays, we try to get them spayed and nuetured but cant seem to ever get them all fixed in time. Our “colony” is at 60+ cats and kittens right now, not to mention the 6 dogs we have as well. The flea meds we were using stopped working and have recently switch brands to advantage 2 for the cats and a generic brand called pet defender+ for the dogs. However we ran out of the advantage before all the cats were dropped. There are about 12 who have not been treated. Is it ok to drop the remaining cats with the drops that are for the dogs? Any help would be greatly appreciated. We are beyond overwhelmed.

    • isak says:

      Wow, 60+. You have me beat.

      I am not familiar with Pet Defender+, but in general, if they make a cat version, compare the ingredients to the dog version. If they are the same, you should be okay. If the product contains permethrin, DO NOT use it on the cats. While dogs can metabolize permethrin effectively, resulting in a safe product for them, cats cannot metabolize this ingredient and will suffer from toxic effects if exposed.

  4. Carrie says:

    I have a question. Sorry if it’s listed somewhere. I have multi-dosed our pets before. I use Frontline Plus. Anyway, I think I bought the extra large dog size and dosed it out from there. I can’t remember since it’s been awhile since I needed to buy new. Do it need to get the extra large for the doses to be correct? Thank you.

    • isak says:

      The dosage is based on the weight of your pets. The extra large will generally cost you less per dose than the smaller sizes and you will get more doses out of the tube. However, if you open a tube and do not use it all, you need to close it tightly and keep it out of the light.

  5. Sharon George says:

    Bless you for all you do. REALLY appreciate this website. I’ve had to switch to Activyl as the Advantages 1 & 2 don’t work anymore, and I can’t buy Revolution w/Paypal in America, not for a decent price, anyway.

    Like everyone else, I rid many rescues and several colonies of fleas, and doing 20+ cats on a fixed income…it has to be as cheap as possible.

    Have you tried Activyl – fleas ONLY for X-large dogs…on cats? I’d love to get a lowdown on the dosages. Thank you!

    Bless you for all you do. We’ve been rescuing cats off our streets for 15 years. I’m a bottle mom. Love it!

    • isak says:

      Thank you for your kind words. And bless you for all you do. I live in the country and somehow, stray cats seem to migrate to my yard despite having dogs (who love cats because they have always lived with cats), so I understand what you are saying. Advantage seems to work for me, but only for 3 weeks max. I’ve read where other people have reported that, too.

      I don’t know much about Activyl, but if the quantity of the active ingredient is the same in both products (for example: 19.53% Indoxacarb in both products), then there is a good chance that the non-tick version can be dosed down for cats. That’s generally the qualifier — same product, same ingredients, different packaging. So based on what the dosages are showing for the different products, you can determine how to dose your cats. Maybe the dosing amount will follow something similar to others we are showing on this post and that will help you micro-tune your dosages.

      Have you tried Sierra Pet Meds for your flea medications? I think they might take PayPal. They generally have good prices and they have a rewards program. I have used them often.

      Let me know what you do and how it works. You aren’t by chance in or near Raleigh, NC, are you? If so, there is a woman with some health/mobility issues who is looking for help with her colony. Any suggestions would be appreciated.

  6. Cris Lenard says:

    I am so very grateful to you for providing this information! We have 5 cats and 2 dogs (all rescues), and I have often been riddled with guilt when funds have been too tight for flea meds (which seems to be too often). All 9 of us (my hubby and self included) THANK YOU, THANK YOU, THANK YOU!!!!!!!!!

  7. Andrea says:

    Thanks so much…I am broke, on a fixed income but I am going to try and donate thru PayPal link provided.

  8. laura says:

    Thanks for posting this! I have been using half-doses of the anti-flea products for years and I have never had a single problem. Here in Michigan, I completely stop dosing around November – March (in my dog-loving neighborhood, I recently discovered that most dog parents are doing the same thing) . The doses given full strength as indicated on the package inserts, when I have tried them, have always made my pets ill for a couple of days after I apply the med. The half-dose works just fine with far less side effects. I wonder if, by poisoning the fleas, we aren’t poisoning the animal at the same time.

    I do get all of the recommended vaccines, though.

  9. Jacqui Rengstorf says:

    Thank you so much for listing all of the dosages for those different products. I’ve been doing the same thing for over 17 years now. I was taught by a wonderful – and spunky!! – little rescue lady ? But I still always like to doublecheck the dosage sizes when I switch products – I don’t want to use too much. The dosages for Advantage and Advantage II are the same, right? I am inquiring for my darling 2 yr old border collie / fox terrier mix named Dodger who weighs 49 pounds, which puts him in the large dog category. Thank You!!

    P. S. I should have mentioned that I have both products on hand. Dodger seems to have a mild allergy to fleas so I wanted to use a Advantage II on him based on what you wrote. While I mentioned him, I do have cats as well so it would be handy to confirm that their dosages with the Advantage II is also the same as the regular Advantage ?

    • isak says:

      Yes, the dosage is the same for Advantage and Advantage II. The difference between the products is this: Advantage required adult fleas to ingest the medication, at which point they would be impacted by the insect-specific neurotoxins and die. Advantage II kills fleas on contact, with the addition of three new chemicals to its formula, that makes your dog or cat’s skin an entirely inhospitable environment for pests. Eggs are killed before they hatch. Adult fleas are killed and will fall off, or will be washed off in your dog’s next bath.

      However be sure you do not use K9 Advantix or Advantix on your cats. It’s a dogs only formula.

  10. Mireille Brosset says:

    Check Dr. Foster & Smith for cheaper multi. They have a sale on this product now.

  11. Kim says:

    Thank you you so much for this info. We live on a farm and have 6 dogs ranging in size from 6 to 95 pounds. I had already.been splitting dosage vials between 2 dogs when appropriate. So recently I thought, why not try to let the product and our money go further by finding out the dose per pound that would be effective. This article was amazing in giving info on all of these products. It was also helpful to find out the important storage info. I wish that more people could be made aware of this info. It seems like it will be good for our pets to have only the necessary amount of insecticide as well. Thanks again for this very informative article.

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